A Heterogeneous-Catalyst-Based, Microwave-Assisted Protocol for the Synthesis of 2,2’-Bipyridines
Submitted by Anonymous on Mon, 08/27/2012 - 13:10
A new method of preparing 2,2’-bipyridines with short reaction times by using microwave assistance and heterogeneous catalysts has been developed. With a Negishi-like protocol, it was found that Ni/Al2O3–SiO2 afforded 2,2’-bipyridine products in up to 86 % yield in 1 h. Palladium supported on alumina also provided yields of 2,2’-bipyridines comparable to those seen for homogeneous PEPPSITM (1,3-diisopropylimidazol-2-ylidene)(3-chloropyridyl)palladium(II)dichloride) and tetrakis(triphenylphosphanyl)palladium complexes.
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